Vapor Compression Systems for Pharmaceutical Manufacturing

MECO is the leading manufacturer of vapor compression distillation systems for the biotechnology, pharmaceutical and life science industries with thousands of installations worldwide. We have the broadest product line of standard and custom systems with production capacities that range from 400 GPH [1,514 LPH] to 7,200 GPH [27,255 LPH]. MECO vapor compression systems produce Water for Injection (WFI) that meet and exceed all cGMP requirements and in accordance with all recognized pharmacopeias.


Technical Data

Note: All VC Still models are available in both hot and cold distillate arrangements.

PES400MSSH400 [1,514]
PES750MSSH750 [2,839]
PES1200MSSH1,200 [4,542]
PES1600MSSH1,600 [6,057]
PES2400MSSH2,400 [9,085]
PES3000MSSH3,000 [11,356]
PES4500MSSH4,500 [17,034]
PES6000MSSH6,000 [22,712]
PES7200MSSH7,200 [27,255]
  • Produces Purified Water (USP Purified), Highly Purified Water (HPW) and Water For Injection (WFI) in accordance with all recognized pharmacopoeias
  • Meets or exceeds the exacting standards of the pharmaceutical industry and cGMP requirements
  • Available individually or as part of a total water treatment solution
  • Superior energy efficiency
  • All fabrication is by MECO in the U.S. (spare parts available)
  • Efficient component layout allows for ease of maintenance and calibration
  • Optional complete validation package with IQ/OQ protocol execution
  • Supported by MECO 24-hour customer service
  • Backed by warranty
Standard Features
  • Unit is completely piped, wired, and assembled on a single skid at the factory
    • Fully functional FAT
    • Reduces installation costs and startup time
  • Vertical natural circulation evaporator
    • Accepts broadest range of feed water quality in the industry
    • Reduces scale effects
    • No circulation pumps or spray nozzles required
    • Straight annealed tubes in evaporator
      • No residual stresses or surface finish problems commonly found with U-tubes
      • Individual tubes can be replaced as opposed to replacing an entire tube bundle
    • Deaeration of feed water
      • Non-condensibles removed prior to distillation
      • Corrosion reduction
    • Hot Stand-by
      • Improved response to distillate demand
      • Allows for steaming of distillate line during hot stand-by
    • Elimination of bio-growth
    • Sanitary construction and connections
    • PLC based controls
    • Variable output standard
    • No oil and oil filter changes
Equipment Details
  • State-of-the-art, direct drive, GII Centurbo™ Compressor
    • Inconel or 2205 Duplex Stainless Steel compressor impeller
    • Directly mounted with no vapor duct work
  • Double tubesheet heat exchangers
  • Sloped piping and low point drains
  • Minimum deadlegs
  • 316/316L SS process contact components
  • 25 Ra μin (0.64 Ra μm) standard process contact surfaces
  • Premium valves and instruments
  • Pneumatic panel houses all pneumatic components
  • Stainless steel air lines
  • Stainless steel hardware
  • Mirror finish stainless steel cladding


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Pharmaceutical Grade Water for Injection (WFI) at Maximum Uptime

What Is Vapor Compression Distillation?

Vapor compression distillation (VC) is a process used to produce Water for Injection (WFI) on the principle of distillation, where the water is distilled with phase change and entrainment separation. In the VC process, the vapor produced by evaporating the water is compressed to increase the saturation pressure and temperature. This compressed vapor is then condensed to produce WFI by transferring its latent heat to infeed water in a heat exchanger.

Features of Vapor Compression

Can produce distillate at ambient temperatures and hot temperatures on demand

Typically has less stringent feed water pretreatment requirements

Provides a simpler pretreatment system

Makes variable production possible

Has a larger capacity, providing more significant utility savings

Benefits of MECO Vapor Compression Systems

The MECO VC features its patented technology, the GII Centurbo™ Compressor. This directly driven variable-speed compressor eliminates the additional parts, maintenance and ineffencies associated with belt drives, gear transmissions and flex couplings. The motor is liquid cooled and incorporates minimum quantity lubrication technology. There’s no recirculating oil system with filters, coolers, pumps, plumbing, valves and instrumentation. No oil and filter changes. Maintenance goes down. Efficiency and reliability go up. You get longer runtime and fewer headaches.

Energy Efficiency

The energy consumption of your distiller represents the largest expenditure over its lifetime. MECO VC plants are the most energy efficient in the industry. Given the same feed water temperature, discharge temperatures and flow rates, the steam consumption of VC distillation plants should nearly be identical and significantly less than other conventional distillation methods. However, MECO’s large surface area evaporators use less electrical power, translating to the lowest cost per thousand gallons produced.